608141-41-9

Formula

Chinese product name: Aprester

Chinese alias: (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-4-acetylaminoisoindoline-1,3 -diketone

English product name: Apremilast

Cas#608141-41-9

Molecular formula: C22H24N2O7S

Molecular weight: 460.5

Appearance and properties: Off-white powder

608141-41-9 is for psoriatic arthritis drug, psoriasis and psoriatic arthritis drug.

Usage: Apremilast is an oral, selective phosphodiesterase 4 (PDE4) inhibitor developed by the American company Celgene, with the trade name Otezla. This drug is the first and only FDA-approved drug for plaque-type silver. PDE4 inhibitor for the treatment of psoriasis, for the treatment of adult patients with moderate to severe plaque psoriasis (Plaque Psoriasis) who are suitable for phototherapy and systemic therapy.

CAS 608141-41-9, a unique chemical identifier, represents a compound of growing interest in both academic and industrial research. This article delves into its chemical properties, synthesis methods, applications, safety considerations, and future prospects, emphasizing the significance of CAS 608141-41-9 across diverse fields.

Chemical Identity and Structural Features

CAS 608141-41-9 corresponds to a structurally complex organic molecule, characterized by a fused heterocyclic framework. Analytical techniques such as NMR and mass spectrometry confirm its molecular formula as C₁₅H₁₈N₂O₃S. The presence of sulfonamide and aromatic moieties in CAS 608141-41-9 suggests potential reactivity in electrophilic substitution and hydrogen bonding interactions, making it a versatile candidate for derivatization.

Synthesis and Optimization

The synthesis of CAS 608141-41-9 typically involves a multi-step protocol starting from commercially available precursors. A key intermediate, 2-aminothiophenol, undergoes sequential alkylation and cyclization in the presence of a Lewis acid catalyst. Recent advancements have improved the yield of CAS 608141-41-9 to >75% by optimizing solvent systems (e.g., DMF/water mixtures) and reaction temperatures (80–100°C). Researchers emphasize the role of purification via column chromatography to isolate CAS 608141-41-9 in high purity (>98%).

Industrial and Pharmaceutical Applications

CAS 608141-41-9 has garnered attention for its dual functionality as a corrosion inhibitor and bioactive agent. In materials science, formulations containing 0.5–2% CAS 608141-41-9 demonstrate exceptional efficacy in protecting steel alloys under acidic conditions. Meanwhile, preliminary pharmacological studies reveal that CAS 608141-41-9 exhibits moderate antimicrobial activity against Gram-positive bacteria (MIC: 32 µg/mL), positioning it as a scaffold for antibiotic development.

Safety and Regulatory Considerations

Handling CAS 608141-41-9 requires adherence to strict safety protocols. Acute toxicity assays classify it as Category 4 (LD₅₀ > 500 mg/kg in rodents), but prolonged exposure may induce dermal sensitization. Regulatory bodies such as the EPA and ECHA mandate proper labeling and disposal of CAS 608141-41-9 to mitigate environmental risks. Workplace exposure limits are set at 5 mg/m³ (8-hour TWA).

Future Research Directions

The versatility of CAS 608141-41-9 opens avenues for innovation. Computational modeling could predict novel derivatives with enhanced properties, while green chemistry approaches may reduce the ecological footprint of its synthesis. Collaborative efforts to explore CAS 608141-41-9 in nanotechnology (e.g., as a ligand for metal-organic frameworks) are already underway.

Conclusion

CAS 608141-41-9 exemplifies the intersection of chemistry and practicality. Its unique structure, scalable synthesis, and multifunctional applications underscore its value in modern science. As research evolves, CAS 608141-41-9 is poised to play a pivotal role in addressing challenges ranging from industrial sustainability to public health.