What is imidazole?

Imidazole is a five-membered aromatic heterocyclic compound with two nitrogen atoms. The hydrogen atom moves between the two nitrogen atoms, so there are two tautomers. Imidazole not only exists in histidine in organisms, but is also a component of purine in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA).

 The imidazole molecule itself has the characteristics of good electron transfer and easy functionalization. Many compounds containing imidazole rings have good biological activity and play an important role in the fields of medicine and pesticides.

Many drugs also contain imidazole rings, such as nitroimidazole and imidazole antifungal agents. In recent years, imidazole compounds have become a research hotspot for the synthesis and application of new nitrogen-containing heterocyclic compounds at home and abroad. Imidazole ring structures are widely present in biological molecules, such as histidine and the corresponding hormone histamine.