Is 5-amino Tetrazole

5-amino Tetrazole is a chemical compound with the molecular formula C2H4N8. It is a white crystalline powder that is soluble in water, and it has a variety of uses in industry and research. The compound is often used as a precursor to other compounds, including pharmaceuticals and agrochemicals.

What are the applications of 5-amino Tetrazole?

5-amino Tetrazole is a versatile chemical compound that has numerous applications. It is used as an initiator for explosives and propellants, and it is also used as a reagent for organic synthesis. Additionally, 5-amino Tetrazole is used to produce dyes, pigments, and other coloring agents.

What are the safety precautions when working with 5-amino Tetrazole?

When working with 5-amino Tetrazole, it is important to take appropriate safety precautions. The compound should be handled in a well-ventilated area, and protective clothing and equipment should be worn at all times. Additionally, care should be taken to avoid ingestion and skin or eye contact with the compound.

What is the molecular structure of 5-amino Tetrazole?

The molecular structure of 5-amino Tetrazole consists of a triazole ring with an amino group attached. The compound has a molecular weight of 116.076 g/mol, and its chemical formula is C2H4N8.

How is 5-amino Tetrazole synthesized?

5-amino Tetrazole is synthesized by reacting sodium azide with nitrous acid. The resulting compound is then treated with hydrochloric acid to yield the final product. The synthesis process requires careful handling and should only be performed by experienced chemists.

What are the potential uses of 5-amino Tetrazole in pharmaceuticals?

5-amino Tetrazole has potential applications in the pharmaceutical industry. The compound has been studied as a potential antitumor agent and as a precursor to pharmaceuticals such as sitagliptin, which is used to treat type 2 diabetes.

In conclusion, 5-amino Tetrazole is a versatile compound with numerous applications in industry and research. It is important to take appropriate safety precautions when working with the compound, and further research may reveal additional potential uses in the pharmaceutical industry.

References:

1. Chen J., Xu Y., Wang Y., et al. (2014). Synthesis and characterization of 5‐amino tetrazole derivative and its application as copper corrosion inhibitor. Corrosion Science, 82, 435-443.

2. Wu G., Zhang Y., Shu X., et al. (2015). Antitumor Activity of 5-Amino-Tetrazole Against Human Hepatocellular Carcinoma In Vitro and In Vivo. Medical Science Monitor, 21, 3822-3829.

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Scientific Research Papers:

1. Zhang L., Sun K., Hoskin D., et al. (2016). Determination of 5-Amino-Tetrazole in a Drug Substance by a Stability-Indicating Ion-Pair LC Method. Journal of Liquid Chromatography & Related Technologies, 39(4), 200-205.

2. Cui H., Yan F., Sun J., et al. (2019). Effects of 5-Amino-Tetrazole on Aggregation and Fibrillogenesis of Lysozyme. International Journal of Peptide Research & Therapeutics, 25(2), 599-605.

3. Yang L., Sun L., Shen J., et al. (2020). Synthesis and Antioxidant Activity of Novel 5-Amino-Tetrazole Derivatives. Russian Journal of Physical Chemistry B, 14(6), 1031-1038.

4. Ma S., Yao J., Wang J., et al. (2018). Design, Synthesis and Evaluation of 5-Amino-Tetrazole Derivatives as MTH1 Inhibitors. European Journal of Medicinal Chemistry, 155, 287-294.

5. Liu J., Wang P., Yan X., et al. (2021). 5-Amino-Tetrazole Directed Design and Synthesis of N-Benzyl Amides as Potent Cholinesterase Inhibitors. International Journal of Molecular Sciences, 22(14), 7422.

6. Chen S., Zhang Y., Wang J., et al. (2017). Synthesis and Characterization of a Novel 5-Amino-Tetrazole-Based Energetic Plasticizer for Propellant. Propellants, Explosives, Pyrotechnics, 42(7), 856-864.

7. Zhang X., Lu J., Xing C., et al. (2020). Multi-Response Optimization of the Synthesis of 5-Amino-Tetrazole Using Response Surface Methodology. Chemical Engineering Communications, 207(4), 482-493.

8. Wan X., Yang Y., Zhang M., et al. (2018). Theoretical Studies of the Effect of Stacking Interactions on the Explosive Properties of 5-Amino-Tetrazole Derivatives. Journal of Molecular Graphics and Modelling, 85, 1-7.

9. Kong W., Liu Y., Chen J., et al. (2019). Synthesis of 5-Amino-Tetrazole Derivatives and Their Antitumor Activities Against Human Hepatocellular Carcinoma Cells. Bioorganic Chemistry, 82, 96-104.

10. Song W., Wang G., Ai H., et al. (2017). Preparation and Properties of 5-Amino-Tetrazole-Based Energetic Thermoplastic Elastomers. Propellants, Explosives, Pyrotechnics, 42(12), 1493-1501.